Pensum/læringskrav

Fra Molecular Biology og the Cell , Fourth Edition (Alberts, B. et al., eds.) 2002, Garland Science, New York and London.

Membrane Structure (kap. 10), side 581-599 (til: cytosolic side of red cells) (19 sider) og side 608-613 (6 sider).

Intracellular compartments and protein sorting (kap. 12), side 659-662 (til: The topological….) (3sider) side 664 (fra: Proteins can move) -667 (til: most membrane-enclosed organelles) (3 sider) The transport between the nucleus and the cytosol (kap. 12), side 669-674 (til: Transport..) (6 sider). The endoplasmic reticulum (kap. 12), side 689-709 (21 sider)

Intracellular vesicular traffic (kap. 13), 711-766 (56 sider)

How cells read the genome from DNA to protein (kap. 6), The proteasome degrades.., side 358-362 (til: Abnormally folded protein) (4 sider).

Cell communication (kap. 15), The three largest classes of cell-surface receptor..842-848 (til: Cells can respond..) (7 sider) Signalling through G-protein-linked cell-surface receptors, side 852- 865 (some G proteins directly regulate ion channels (13 sider)

The cytoskeleton (kap. 16), side 907-917 (to “Fimament treadmilling..”(10sider), “Filament polymerization can be altered by drugs” s.927- (1side), og Extracellular signals side 947-959 (til: motor protein function can be regulated) (13 sider)

Totalt fra læreboken: 162 sider

 Membrane composition (including lipids) and fusion/fission

The complex life of simple sphingolipids (Futerman, A.H. and Hannun, Y.A., EMBO reports 5 (2004) 777-782 (5 sider)).

Lipid rafts and membrane dynamics (Rajendran,L. and Simons, K., J.Cell Sci. 118 (2005) 1099-1102 (4sider)).

Membrane curvature and mechanisms of dynamic cell membrane remodelling ( McMahon, H.T., and Gallop, J.L, Nature 438 (Dec. 2005) 590-596 (6 sider)).

Transmembrane asymmetry and lateral domains in biological membranes (Devaux, P.F. and Morris, R. Traffic 5 (2004) 241-246 (6 sider)).

Probing phosphoinositide functions in signaling and membrane trafficking (Downes, C. P., Gray, A., and Lucocq, J.M., Trends Cell Biol. 15 (2005) 259-268 (8 sider)).

Molecular motors

Microtubule motors at the intersection of trafficking and transport (Caviston, J.P. and Holzbaur, E.L.F., Trends Cell Biol. 16 (2006) 530-537 (7 sider)).

 Endocytosis

Evolving endosomes: how many varieties and why? (E. Perret, A. Lakkaraju, S. Deborde, R. Schreiner and Rodriquez-Boulan, Curr. Opin. Cell Biol. 17 (2005) 423-434. (9 sider)).

Virus entry: Open sesame (Marsh, M. and Helenius, A., Cell 124 (2006) 729-740 (8 sider)).

Molecular ticket to enter cells (Oved, S. and Yarden, Y., Nature 416 (2002) 133-136 (4 sider)).

Dynamin at the actin-membrane interface (J.D. Orth and M.A. McNiven, Current Opin. Cell Biol. 15 (2003) 31-39, 7 sider).

Filling the GAP for dynamin (Hinshaw, J.E., Nature Cell Biol. 8 (2006) 432-433 (2 sider)).

Endocytic adaptors: recruiters, coordinators and regulators (Maldonado-Baez, L. and Wendland, B., Trends Cell Biol. 16 (2006) 505-513 (7 sider)).

Adaptable adaptors for coated vesicles (M. Robinson, Trends Cell Biol. vol 14 (2004) 167-174 (8 sider)).

Caveolae: Stable membrane domains with a potential for internalization (Hommelgaard A. et al., Traffic 6 (2005) 720-724 (4sider)).

 Exosomes

The ins and outs of exosomes (Couzin, J. Science 308 (2005) 1862-1863 (2 sider)).

 Endosomal coat proteins and sorting

Controlling the location and activation of Rab GTPases (M.C. Seabra and C. Wasmeier, Curr.Opin.Cell Biol. 16 (2004) 451-457 (7 sider).

Retrograde transport from endosomes to the trans-Golgi network (Bonifacino, J. and Rojas, R., Nature reviews 7 (2006) 569-579 (11 sider)).

Molecular mechanisms of late endosome morphology, identity and sorting (Russell, M.R.G., Nickerson, D.P., and Odorizzi, G., Curr. Opin. Cell Biol. 18 (2006) 422-428 (5 sider)).

No ESCRT to the melanosome: MVB sorting without ubiquitin (Katzmann, D.J., Developmental Cell 10 (2006) 278-280 (2 sider)).

Endoplasmic reticulum og ER-Golgi transport

Structural insight into the protein translocation channel (Clemons, WM, Ménétret, JF, Akey, CW, and Rapoport, TA, Curr.Opin.Struct.Biol. 14 (2004) 390-396 (7 sider))

Peptide presentation by MHC class I molecules (Williams et al. Trends in Cell Biol. vol. 6 (1996) 267-273) (7 sider).

Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum (Williams, D.B., J. Cell Sci. 119 (2006) 615-623 (7 sider)).

A channel for protein waste (R. Scheckman, Nature, vol. 429 (2004) 817-818).

Exiting the endoplasmic reticulum (Mancias, J.D., and Goldberg, J. Traffic 6 (2005) 278-285 (6 sider)).

 Golgi and sorting from the Golgi

Protein sorting in the Golgi complex: Shifting paradigms (E. Rodiriguez-Boulan and A. Müsch) BBA 1744 (2005) 455-464 (7 sider)).

Global approaches to study Golgi function (Mogelsvang, S. and Howell, K.E., Curr.Opin. Cell Biol. 18 (2006) 438-443 (4 sider)).

The Golgi grows up (Malhotra V. and Mayor, S., Nature 441 (2006) 939-940 (2 sider)).

Vesicle formation at the plasma membrane and trans-Golgi network: the same but different (McNiven, M. and Thompson, H.M., Science 313 (2006) 1591-1594 (4 sider)).

 Toxins

Rho proteins:targets for bacterial toxins (Klaus Aktories, Trends in Microbiol. vol. 282 (1997) 282-288).

Delivery into cells: lessons learned from plant and bacterial toxins (Sandvig, K. and van Deurs, B., Gene therapy 12 (2005) 665-672 (6 sider)).

Published Apr. 24, 2006 11:46 PM - Last modified Oct. 10, 2006 5:22 PM