Pensum/læringskrav

1. Lærebøker:

• Branden and Tooze ´Introduction to protein structure', 2. utgave (1999) ISBN 0815323050

• Voet and Voet ´Biochemistry', 3. utgave (2004) ISBN 0471392235

2. Forelesningsnotater

3. Tidsaktuelle artikler (maks. 20 sider)

[Generell strukturkjemi som kun dekkes av forelesningene vil ikke være grunnlag for direkte eksaminasjon, men sentrale begreper forutsettes kjent]

Detaljert beskrivelse av pensumet i lærebøkene

Brändén and Tooze

Kap. 1. The building blocks 1-12

Kap. 2. Motifs of Protein Structure 12-33

Kap. 3. Alpha-Domain Structures 35-45

Kap. 4. Alpha/Beta Structures 47-64

Kap. 5. Beta Structures 67-87

Kap. 7. DNA Structures 121-125

Kap. 8. DNA Recognition in Procaryotes by Helix-Turn- Helix Motif 131-135 + 138-141 (129-131 og 135-137 kursorisk)

Kap. 10. Specific Transcription Factors Belong to a Few Families 175-181 + 191-196

Kap. 11. An Example of Enzyme Catalysis: Serine Proteinases 205-220

Kap. 12. Membrane Proteins 223-248 (234-246 delvis kursorisk)

Kap. 14. Fibrous Proteins 283-290

Kap. 15. Recognition of Foreign Molecules by the Immune Systems 299-321

Kap. 16. The Structure of Spherical Viruses 325-338

Voet & Voet

Noe av stoffet nedenfor er supplerende stoff/overlapp med Brändén & Tooze. 3rd edition

Kap. 4. Amino acids

• 1. The amino acids of proteins 65-71
• 2. Optical activity 71-76
• 3. ´Nonstandard Amino Acids 76-76 (A)

Kap. 5. Nucleic Acids, Gene Expression, and Recombinant DNA Technology

• 1. Nucleotides and Nucleic Acids 80-82
• 3. Double Helical DNA 85-88 (A)

Kap. 8. Three-Dimentional Structures Of Proteins

• 3. Globular Proteins 255-258 (D)
• 4. Protein Stability 258-263 (A, B, C, D)

Kap. 9. Protein Folding, Dynamics and Structural Evolution

• 1. Protein Folding: Theory and Experiment 276-288
• 2. Folding Accessory Proteins 288-299
• 3. Protein Structure prediction and design 299-302
• 4. Protein Dynamics 302-306
• 5. Conformational Diseases: Amyloid and prions 306-312

Kap. 10. Hemoglobin: Protein Function in Microcosm

• 1. Hemoglobin Function 320-322 (A)
• 2. Structure and Mechanism 327-337 (A, B, C)
• 3. Abnormal Hemoglobins 339-345 (A)

Kap. 11. Sugars and Polysaccharides

• 1. Monosaccharides 356-362
• 2. Polysaccharides 362-369
• 3. Glycoproteins 369-379

Kap. 15. Enzymatic Catalysis

• 4. Drug Design 528-541 (528-534 Kursorisk)

Kap. 29. Nucleic Acid Structures and Manipulation

• 2. Double helical structures 1107-1115
• 3. Forces stabilizing nucleic acid structures 1115-1122

Kap. 31. Transcription

• 1. The role of RNA in protein synthesis 1216-1221 (Kursorisk)

Kap. 32. Translation

• 2. tRNA and its aminoacylation 1292-1296
• 3. Ribosomes 1309-1318 (A)

Kap. 33. Viruses: Paradigms For Cellular Functions

• 1. Tobacco Mosaic Virus 1372-1379
• 2. Icosahedral Viruses: 1379-1390
• 4. Influenza virus 1408-1417

Kap. 35. Eucaryotic gene expression

• 1. Chromosome Structure 1422-1431

Totalt ca. 350 sider (overlapp ikke inkludert)

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EKSTRA: Alternativ anskueliggjøring av deler av pensum

Kap. 8. Three-Dimentional Structures of Proteins

• 1. Secondary Structures 219-231
• 2. Fibrous Proteins 231-240
• 3. Globular Proteins 240-255

Kap. 15. Enzymatic Catalysis

• 3. Serine proteases 515-527 (A, B, C, D)

Kap. 31. Transcription

• 3. Control of transcription in prokaryotes 1242-1245 (D)

Kap. 35. Molecular Physiology

• 2. Immunity 1207-1234 (2. utgave nummerering)